Lee Wai Leng

Lecturer

PhD (Academia Sinica and National Chung Hsing University, Taiwan)

Email: lee.wai.leng@monash.edu
Telephone: (+603) 5514 6000, ext: 46098 (DID: 5514 6098)
Room number: 4-8-37 (Building 4, Level 8, No. 37)
  • Discovery of novel targetable pathways in cancer treatments - Several novel signaling pathways in breast cancer were discovered in my previous study. Among the components involved in these pathways, exosome is an extremely intriguing target in cancer treatment. Currently, one of the research projects in my laboratory aims to investigate the links between oncogenic mutation and exosome-mediated carcinogenesis. 
  • Development of novel treatment options involve phytochemicals to provide breakthrough in treating life-threatening cancer diseases - Concerns about drug resistance and side effects of currently used therapeutic agents have raised interest in phytochemicals derived from dietary foods and traditional medicines which allow safe and continuing ingestion. Therefore my research also aims to discover the therapeutic use of local medicinal plant-derived phytochemicals in cancer treatment.

Selected Journal Papers

Wai-Leng Lee, Jing-Ying Huang and Lie-Fen Shyur. (2013). Phytoagents for cancer management: regulation of nucleic acid oxidation, ROS, and related mechanisms. Oxidative Medicine and Cellular Longevity. Special Issue: Nucleic Acid Oxidation in Human Health and Disease. Vol 2013: 925804. DOI: 10.1155/2013/925804.

Lie-Fen Shyur, Wai-Leng Lee, Jeng-Yuan Shiau, Laiqiang Ying, Jacquelyn Gervay-Hague. (2013). Optical imaging of molecular targets of phytoagent deoxyelephantopin against mammary adenocarcinoma cell activities. FASEB Journal. 27: 663.1. 

Deoxyelephantopin impedes mammary adenocarcinoma cell motility through inhibiting calpain-mediated adhesion dynamics and inducing ROS and aggresome formation. Free Radical Biology & Medicine 2012 52: 1423-1436. Wai-Leng Lee and Lie-Fen Shyur.

Differential proteomic profiling identifies novel molecular targets of paclitaxel and phytoagent deoxyelephantopin against mammary adenocarcinoma cells. Journal of Proteome Research 2010 9: 237-253. Wai-Leng Lee, Tuan-Nan Wen, Jeng-Yuan Shiau and Lie-Fen Shyur.

Ethnobotany, Cancer Cell Biology, Proteomics

Book Chapter

Peng-Nian Yew, Kan-Fu Oh and Wai-Leng Lee. (2015) Pro-oxidative phytoagents induce autophagy in tumors: Villain or benefactor in cancer treatment? AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, M. A. Hayat (Editor), Elsevier. (Book chapter in revision) 

Wai-Leng Lee, Jeng-Yuan Shiau and Lie-Fen Shyur (2012) Taxol, camptothecin and beyond for cancer therapy. pp 133-178. In: Lie-Fen Shyur (ed.) Advances in Botanical Research (Vol. 62): Recent Trends in Medicinal Plants Research. Elsevier.

Chun-Hung Lin, Wai-Leng Lee and Lie-Fen Shyur (2011) An overview of the current development of phytoremedies for breast cancer. pp 47-67. In: William Cho (ed.) Materia Medica for Various Cancers: Evidence-Based Anticancer Complementary and Alternative Medicine 2. Springer Science+Business Media B.V.

Patent

Lie-Fen Shyur, Jia-Hua Feng, Wai-Leng Lee, Jo-Yu Chen, Yu-Ting Cheng, Jing-Ying Huang, Kuo-Hsiung Lee, Kyoko Nakagawa Goto. “NOVEL SESQUITERPENE DERIVATIVES AND THEIR USE IN INFLAMMATION AND CANCER TREATMENT” Attorney Docket No. 10011-044PCT, pending.

PhD Students (Present)

  1. Eng Shu Kee
  2. Khoo Xin Hui

Honours Students (Present)

  1. Ilma Ruzni Imtiaz

Honours Students (Completed)

  1. Lee Hui Mei
  2. Shih Chih Tao
  3. Clairissa Joan Ping Ping Lee
  4. Nurul Syuhada Zulhaimi