Sunil K. Lal

Professor of Microbiology

PhD in Microbial Genetics (Georgia Tech. USA)

Email: sunil.lal@monash.edu
Telephone: (+603) 5514 6000, ext: 59606
Room number: 4-8-16 (Building 4, Level 8, No. 16)

Molecular Virology and Emerging Infectious Diseases. Molecular Biology of Host-Virus interactions. Genomic, transcriptomic and proteomic approaches to understanding host-virus relationships. Cell Death and Suvival pathways. Cell signalling and cell cycle progression. Cellular NF-kB, Enolase/S100A8, ubiquitin ligase and  chaperone mediated modulation of host pathways by influenza viruses. Viral strategies to overcome host innate immune responses. 

Selected Journal Papers

H. Nailwal, S. Sharma, A. K. Mayank, S. K. Lal. 2015. The Nucleoprotein of Influenza A virus induces p53 signaling and apoptosis via attenuation of host Ubiquitin ligase RNF43. Cell Death & Disease  (in press)

S. Sharma, A. K. Mayank, S. Tripathi, J. R. Patel, P. Gaur, R. O. Donis, J. M. Katz, N. J. Cox, R. B. Lal, S. Sambhara, S. K. Lal. 2014. Influenza A viral nucleoprotein interacts with cytoskeleton scaffolding protein α-actinin-4 for viral replication. The FEBS J. (in press; doi:10.1111/febs.12828)

S. Tripathi, W. Cao, K. Sharma, J.R. Patel, P. Ranjan, J. M. Katz, N. J. Cox, R. B. Lal, S. Sambhara, S. K. Lal. 2013. Influenza A virus Nucleoprotein induces cell death in human lung epithelial cells by targeting Clusterin. Cell Death & Disease 4: e562; doi:10.1038 / cddis.2013.89

S. N. Khan, M. Danishuddin, B. Varshney, S. K. Lal, A. U. Khan. 2012. Inhibition of N-terminal lysines acetylation and transcription factor assembly byepirubicin induced deranged cell homeostasis. PLoS ONE 7(12):e51850.

P. Gaur, P. Ranjan, S. Sharma, J.R. Patel, J.B. Bowzard, S. K. Rahman, R. Kumari, S. Gangappa, J.M. Katz, N.J. Cox, R.B. Lal, S. Sambhara, S. K. Lal. 2012. Influenza A virus Neuraminidase protein enhances cell survival through interaction with CEACAM6. J. Biol. Chem. 287:15109-15117.

B. Varshney, S. Agnihotram, Y-J Tan, R. Baric, S. K. Lal. 2012. SARS Coronavirus 3b protein modulates transcriptional activity of RUNX1b. PLoS ONE 7(1):e29542.

K. Sharma, S. Ackerstorm, A. K. Sharma, V.T.K. Chow, S. Teow, B. Abrenica, S. A. Booth, T. F. Booth, A. Mirazimi, S. K. Lal. 2011. SARS-CoV 9b protein diffuses into nucleus, undergoes active crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus. PLoS ONE 6(5): e19436.

K. Sharma, S. Tripathi, P. Ranjan, P. Kumar, R. Garten, V. Deyde, J. M. Katz, N. J. Cox, R. B. Lal, S. Sambhara, S. K. Lal. 2011. Influenza A virus Nucleoprotein exploits Hsp40 to inhibit PKR activation. PLoS ONE 6(6): e20215.

S. Karjee, A. Minhas, V. Sood, S. S. Ponia, A. C. Banerjea, V. T. K. Chow, S. K. Mukherjee, S. K. Lal. 2010. The 7a accessory protein of SARS-CoV acts as a RNA silencing suppressor. J. Virol. 84:10395-10401.

H-L. J. Oh, S. Akerstrom, S. Shen, S. Bereczky, H. Karlberg, J. Klingström, S. K. Lal, A. Mirazimi, Y-J Tan. 2010. An antibody against a novel and conserved epitope in the 1 HA1 subunit neutralizes numerous H5N1 influenza viruses. J. Virol. 84: 8275-8286.

 

Book Chapters

N. Shanker, S. K. Lal. 2011. SAARC nations and the risk of Influenza (ed. S. Soz, R. N. Srivastava & S. Gupta) SAARC Building Bridges in the South Asian Region. New Delhi. p331-344.

M. Surjit, S. K. Lal. 2010. ORF3 protein of Hepatitis E virus: possible structural and regulatory functions during viral pathogenesis. (eds. D. Raghunath & V. Nagaraja) Mechanisms of microbial pathogenesis. Macmillan, Bangalore. p168-182.

M. Surjit, S. K. Lal. 2010. The nucleocapsid protein of the SARS Coronavirus: structure, function and therapeutic potential. (ed. S. K. Lal) Molecular Biology of the SARS-Coronavirus. Springer. Germany. p129-151.

J. Pramod, S. Sharma, S. Goyal, K. Soni, M. Chaudhery, S.K. Lal. 2010. Prevalent, Sustained and Emerging Bacterial & Viral Infections: a growing challenge for SAARC nations. (ed. S. Soz & R. N. Srivastava) SAARC Emerging challenges. New Delhi. p227-242.

K. Sharma, S. K. Lal. 2009. Potential Disasters – infectious viral diseases. (ed. K. K. Singh) Disaster Management. Section 6, Chapter 25. Ashish Publishing House Corporation, New Delhi.

N. Shanker, S. K. Lal. 2009. The molecular biology of emerging viral diseases. (ed. A. K. Chauhan & A. Varma) A Textbook of Molecular Biotechnology. IK International Publishing House Pvt. Ltd., New Delhi. (ISBN 978-93-80026-37-4), p879-904.

S. K. Lal. 2008. The threat of emerging viral diseases in SAARC nations. (ed. I. A. Saradgi, S. K. Sahni & R. N. Srivastava) SAARC Socio-Economic Transformation. Foundation for Peace & Sustainable Development, New Delhi. (ISBN 81-903823-1-4), p255-262.

Books

Sunil K. Lal (2006) Emerging Viral Diseases of South-East Asia. Karger. ISBN-10: 3-8055-8175-0

Sunil K. Lal (2007) The Biology of Emerging Viruses.  ISBN-978157331-690-3; Pages: 250

Hemant J. Purohit, Jitender P. Khurana, Rakesh Sharma, Sunil K. Lal & Vipin C. Kalia (2008) Indian Journal of Microbiology. Special Issue on Bacterial Diversity, Genomics & Metagenomics. Springer. ISSN-0046-8991

Sunil K. Lal (2010) Molecular Biology of the SARS-Coronavirus. Springer. ISBN 3642036821, 9783642036828

Sunil K. Lal (2009) Indian Journal of Microbiology. Special Issue on Swine Flu Pandemic. Springer. ISBN 3642036821

Patent

A process for producing recombinant Matrix 1 protein (M1) Capsid Like Proteins (CLPs) and their use as potential influenza vaccine candidate. Vahid Baniasadi & Sunil K. Lal. Indian Patent Application No. 91/DEL/2013; Application filed: 2013