Yeong Keng Yoon, Ken

Lecturer

PhD (Universiti Sains Malaysia)

Email: yeong.kengyoon@monash.edu
Telephone: +603 5514 6000 Ext: 46102 (DID: 5514 6102)
Room number: 4-8-20

Yeong Keng Yoon, Hasnah Osman, Tan Soo Choon 2016, Potent sirtuin inhibition with 1,2,5-trisubstituted benzimidazoles, MedChemComm, Accepted manuscript. DOI: 10.1039/C6MD00378H

Yeong Keng Yoon, Oon Chern Ein 2016, Sirtuin inhibitors: An overview from medicinal chemistry perspective, Anticancer Agents Med. Chem., 16, 1003-1016.

Yeong Keng Yoon, Tan Soo Choon 2016, Sirtuin inhibitors: Structural modification of benzimidazoles via multi-step synthesis and their impact on activity, Arch. Pharm. Chem. Life Sci., 349, 1-8.

Yeong Keng Yoon, Mohamed Ashraf Ali, Ang Chee Wei, Tan Soo Choon, Amir Nasrolahi Shirazi, Keykavous Parang 2015, Discovery of a potent and highly fluorescent sirtuin inhibitor, MedChemComm, 6, 1857-1863.

Yeong Keng Yoon, Mohamed Ashraf Ali, Ang Chee Wei, Tan Soo Choon, Rusli Ismail 2015, Synthesis and evaluation of antimycobacterial activity of new benzimidazole aminoesters, European Journal of Medicinal Chemistry, 93, 614-624.

Oon Chern Ein, Carina Strell, Yeong Keng Yoon, Arne Östman, Jai Prakash 2015, SIRT1 inhibition in pancreatic cancer models: Contrasting effect in vitro and in vivo, European Journal of Pharmacology, 757, 59-67.

Ang Chee Wei, Mohamed Ashraf Ali, Yeong Keng Yoon, Choi Sy Bing., Hasnah Osman, Vijay Masand, Tan Soo Choon 2015, Antimycobacterial activity and in silico study of highly functionalised dispiropyrrolidines, Medicinal Chemistry Research, 24, 818-828. 

Yeong Keng Yoon, Mohamed Ashraf Ali, Ang Chee Wei, Amir Nasrolahi Shirazi, Keykavous Parang, Tan Soo Choon 2014, Benzimidazoles as new scaffold of sirtuin inhibitors: Green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties, European Journal of Medicinal Chemistry, 83, 448-454.

Yeong Keng Yoon, Mohamed Ashraf Ali, Ang Chee Wei, Tan Soo Choon, Hasnah Osman 2014, A one-pot tandem synthesis of various 1,2-disubstituted benzimidazoles, Tetrahedron Letters, 55, 4697-4700.

Yeong Keng Yoon, Mohamed Ashraf Ali, Ang Chee Wei, Tan Soo Choon, Hasnah Osman, Keykavous Parang, Amir Nasrolahi Shirazi 2014, Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities, Bioorganic and Medicinal Chemistry, 22, 703-710.

Yeong Keng Yoon, Mohamed Ashraf Ali, Ang Chee Wei, Tan Soo Choon, Lim Wan Leng, Oo Chuan Wei 2014, Total synthesis of diversified 1,2-disubstituted benzimidazoles with green approach at room temperature, Letters in Organic Chemistry, 11, 785-789.  

Ang Chee Wei, Mohamed Ashraf Ali, Yeong Keng Yoon, Rusli Ismail, Tan Soo Choon., Khaw Kooi Yeong., Vikneswaran Murugaiyah, Venu Sanjeevi Lakshmipathi 2014, Synthesis of highly functionalised dispiropyrrolidine derivatives as novel acetylcholinesterase inhibitors, Letters in Drug Design and Discovery, 11, 156-161.

Yeong Keng Yoon, Mohamed Ashraf Ali, Ang Chee Wei, Tan Soo Choon, Khaw Kooi Yeong, Vikneswaran Murugaiyah, Hasnah Osman H., Vijay Masand 2013, Synthesis, characterization and molecular docking analysis of novel benzimidazole derivatives as cholinesterase inhibitors, Bioorganic Chemistry, 49, 33-39.

Yeong Keng Yoon, Mohamed Ashraf Ali, Tan Soo Choon, Rusli Ismail, Ang Chee Wei, Raju Suresh Kumar, Hasnah Osman, Farzana Beevi 2013, Antituberculosis: Synthesis and antimycobacterial activity of novel benzimidazole derivatives, BioMed Research International, 926309. 

Mohamed Ashraf Ali, Venu Sanjeevi Lakshmipathi, Farzana Beevi, Raju Suresh Kumar, Rusli Ismail, Tan Soo Choon, Ang Chee Wei, Yeong Keng Yoon, Alireza Basiri 2013, Antimycobacterial Activity: synthesis and biological evaluation of novel substituted (3E,5E)-3,5-diarylidene-1-phenethylpiperidine-4-one derivatives, Letters in Drug Design and Discovery, 10, 471-476. 

Ang Chee Wei, Mohamed Ashraf Ali, Yeong Keng Yoon, Rusli Ismail, Tan Soo Choon, Raju Suresh Kumar 2013, A facile three-component [3+2]-cycloaddition for the regioselective synthesis of highly functionalised dispiropyrrolidines acting as antimycobacterial agents, Bioorganic and Medicinal Chemistry Letters, 23, 1383-1386.

Ang Chee Wei, Mohamed Ashraf Ali, Yeong Keng Yoon, Rusli Ismail, Tan Soo Choon, Raju Suresh Kumar, Arumugam Natarajan, Abdulrahman Almansour, Hasnah Osman 2012, Antimycobacterial activity: A facile three-component [3+2]-cycloaddition for the regioselective synthesis of highly functionalised dispiropyrrolidines, Bioorganic and Medicinal Chemistry Letters, 22, 4930-4933.

Adbulrahman Almansour, Mohamed Ashraf Ali, Sadath Ali, Ang Chee Wei, Yeong Keng Yoon, Rusli Ismail, Tan Soo Choon, Suresh Pandian, Raju Suresh Kumar, Arumugam Natarajan, Hasnah Osman 2012, Antimycobacterial Agents: Synthesis and Biological Evaluation of Novel 4-(Substituted-phenyl)-6-methyl-2-oxo-N-(pyridin-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide Derivatives by Using One-pot Multicomponent Method, Letters in Drug Design and Discovery, 9, 953-957. 

Mohamed Ashraf Ali, Rusli Ismail, Tan Soo Choon, Yeong Keng Yoon, Ang Chee Wei, Suresh Pandian, Jeyabalan Samy, Eric De Clercq, Christophe Pannecouque C. 2011, Synthesis and anti-HIV activity of novel 3-substituted phenyl-6,7-dimethoxy-3a,4-dihydro-3H-Indeno[1,2-c]Isoxazole analogues, Acta Poloniae Pharmaceutica-Drug Research, 68, 343-348.

Raju Suresh Kumar, Mohamed Ashraf Ali, Hasnah Osman, Rusli Ismail, Tan Soo Choon, Yeong Keng Yoon, Ang Chee Wei, Suresh Pandian, Elumalai Manogaran 2011, Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase, Bioorganic and Medicinal Chemistry Letters, 21, 3997-4000.

Mohamed Ashraf Ali, Rusli Ismail, Tan Soo Choon, Yeong Keng Yoon, Ang Chee Wei, Suresh Pandian, Raju Suresh Kumar, Hasnah Osman, Elumalai Manogaran 2010, Substituted spiro [2.3’] oxindolespiro[3.2’’]-5,6-dimethoxy-indane-1’’-one-pyrrolidine analogue as inhibitors of acetylcholinesterase, Bioorganic and Medicinal Chemistry Letters, 20, 7064-7066.

  • Medicinal chemistry
  • Drug design and discovery
  • Organic synthesis
  • Immunoassay development

Awards

  • Persada Kencana (Golden Pavilion Award) for Best Research Project (2015), Universiti Sains Malaysia
  • Best Publishing Award (2011), Universiti Sains Malaysia
  • MyBrain15 Scholarship, Ministry of Education Malaysia

Patents

  • BZD9L1: A novel antiangiogenic agent (APPLICATION NO: PCT/MY2016/050057) 
  • BZD9L1: A novel anticancer agent (APPLICATION NO: PCT/MY2016/050058) 
  • Compound And Method For Inhibiting Sirtuin Activities (APPLICATION NO: PCT/MY2016/050029) 
  • A fluorescent dye compound (APPLICATION NO: PI 2014703421) 
  • Cucurmin Compounds and Their Preparation Thereof. WIPO-PCT (WO2012/099454A1) 
  • Pyrrolothiazole Containing Cucurmin Compounds. WIPO-PCT (WO2012/099453A1) 
  • Cucurmin Compounds with Superior Structural Stability and Processes for their Preparation Thereof. WIPO-PCT (WO2012/099452A1) 
  • Cucurmin Compounds Containing Indolizine and Their Preparation Thereof. WIPO-PCT (WO2012/099451A1) 

Research Collaboration

  • University of Northern British Columbia
  • Universiti Sains Malaysia
  • Universiti Malaya

Journal Reviewer

  • Tetrahedron Letters (Elsevier)
  • European Journal of Medicinal Chemistry (Elsevier)
  • Bioorganic and Medicinal Chemistry (Elsevier)
  • Current Medicinal Chemistry (Bentham Science)
  • PLOS ONE (PLOS)
  • Medicinal Chemistry Research (Springer)
  • Journal of Agricultural and Food Chemistry (ACS)